QUINOLINIC ACID EXCRETION AND METABOLISM IN MAN
نویسندگان
چکیده
منابع مشابه
Quinolinic acid excretion and metabolism in man.
In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...
متن کاملQuinolinic Acid Metabolism
Since the observation (1) that tryptophan and nicotinic acid are mutually interchangeable, within limits, in supporting the growth of rats, considerable evidence has accumulated which indicates that biosynthesis of nicotinic acid can proceed from tryptophan (2-5). Unequivocal evidence for this transformation was provided by the experiments of Heidelberger et al. (6) who fed labeled tryptophan @...
متن کاملMetabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Neurologic symptoms and neurodegeneration are important causes of morbidity and mortality in man. Although many pathogenic mechanisms could account for neurologic dysfunction, considerable interest has focused on a group of neurotoxins known as the ‘excitotoxins’. Quinolinic acid (QUIN) is an excitotoxic L-tryptophan and kynurenine pathway metabolite that is an agonist of N-methyl-uaspartate (N...
متن کاملQuinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region.
Quinolinic acid (QUIN) is a potent endogenous excitotoxin, which has been shown to be present in the brain (Wolfensberger et al., 1983). In order to study the cellular localization of QUIN metabolism in the hippocampus, specific antibodies raised against purified rat liver 3-hydroxyanthranilic acid oxygenase (3HAO) and quinolinic acid phosphoribosyltransferase (QPRT), the enzymes directly respo...
متن کاملOrotic acid excretion and arginine metabolism.
The urinary excretion of orotic acid, an intermediate in the pyrimidine biosynthetic pathway, is markedly increased in many inborn errors of the urea cycle and in a number of other disorders involving arginine metabolism. Carbamoyl phosphate, which accumulates within hepatic mitochondria in patients with ornithine transcarbamoylase deficiency, can diffuse to the cytosol and enter the pyrimidine...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)50919-4